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KMID : 1134819980270040712
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Journal of the Korean Society of Food Science and Nutrition
1998 Volume.27 No. 4 p.712 ~ p.717
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Inhibition Effects of Auricularia auricula - judae Methanol Extract on Lipid Peroxidation and Liver Damage in Benzo(a)pyrene - Treated Mice
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Chang Jong-Sun
Kim Hyun-Jeong
Bae Jun-Tae
Park Sun-Hee
Lee Sung-On
Kim Og-Mi
Lee Kap-Rang
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Abstract
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This study was undertaken to investigate the inhibition effects of Auricularia auricula-judae methanol extract in edible mushroom on lipid peroxidation and liver damage in benzo(a)pyrene(B(a)P)-treated mice. The activities of serum aminotransferase, cytochrome P-450, superoxide dismutase, catalase, glutathione peroxidase and the hepatic content of lipid peroxide after B(a)P-treatment were markedly increased than control but those levels were significantly decreased by the treatment of Auricularia auricula-judae methanol extract. Glutathione S-transferase activity and the hepatic glutathione content were decreased by B(a)P-treatment than control, but those were also inhibited by the treatment of Auricularia auricula-judae methanol extract. These results suggest that Auricularia auricula-judae methanol extract have a protective effect on liver damage by B(a)P.
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KEYWORD
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Auricularia auricula-judae, benzo(a)pyrene
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